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Life Sciences Series A Founded 2012

Neurolief

Neurolief is a developer of a wearable neuromodulation platform technology for brain stimulation, with an FDA-approved product called Proliv Rx. The Proliv Rx System provides focal external Combined Occipital and Trigeminal Afferent Stimulation (eCOT-AS) treatment as an adjunctive therapy for Major Depressive Disorder in adults who failed to achieve satisfactory improvement from at least one previous antidepressant…

📍 Herzliya, Israel · Neurology,

Funding snapshot

Last roundSeries A
Amount$6M
Date30 March 2026
Total raised$11M
Team size30

About

Neurolief is a developer of a wearable neuromodulation platform technology for brain stimulation, with an FDA-approved product called Proliv Rx. The Proliv Rx System provides focal external Combined Occipital and Trigeminal Afferent Stimulation (eCOT-AS) treatment as an adjunctive therapy for Major Depressive Disorder in adults who failed to achieve satisfactory improvement from at least one previous antidepressant medication. It is the only at-home brain neuromodulation therapy available for this patient population, delivered as a prescription-only device for use at home or in clinic. The treatment features a structured 8-16 week program with physician oversight, continuous adherence and symptom tracking, and no additional clinic equipment or staffing requirements. Clinical outcomes include 87% demonstrated improvement in depression severity, 96% full adherence to treatment protocol, and an estimated 35,000 dollars in annual savings per patient through reduced escalation to in-clinic neuromodulation, emergency room visits, and inpatient utilization. Proliv Rx serves health systems, VA VISNs and veterans, clinicians, and patients and families. Founded in 2012 and headquartered in Herzliya, Israel, Neurolief has raised approximately 11 million at the Series A stage with investors including Terra Venture Partners, Brainsway, KT Squared, and Champel Capital.

Business model

Wearable Technology > Health and Wellness Devices > Mental Wellness,

Disease Self Management > Neurological Disorders > Therapy > Psychological > Device > Wearable,

Neurology > Medical Devices > Therapeutic Devices > Psychiatric > Depression

Institutional investors

Terra Venture Partners Brainsway KT Squared Champel Capital

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